Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.54 |
| ▸ | PARP1 | P09874 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19456155 | 0.90 | BRD4 (0.45) | BRD4PARP1 | |
| SCHEMBL19456169 | 0.90 | PARP1 (0.49) | BRD4PARP1 | |
| SCHEMBL21649727 | 0.86 | PARP1 (0.43) | BRD4PARP1 | |
| SCHEMBL21649796 | 0.86 | BRD4 (0.48) | BRD4PARP1 | |
| SCHEMBL19456124 | 0.86 | BRD4 (0.41) | BRD4PARP1 | |
| SCHEMBL19456310 | 0.85 | BRD4 (0.49) | BRD4 | |
| SCHEMBL19456213 | 0.85 | BRD4 (0.43) | BRD4PARP1 | |
| SCHEMBL19456334 | 0.84 | BRD4 (0.48) | BRD4 | |
| SCHEMBL19456258 | 0.84 | TDP1 (0.50) | BRD4PARP1 | |
| SCHEMBL21649801 | 0.84 | BRD4 (0.50) | BRD4PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440075-B1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-01-29 | — | — | EP | disclosed |
| WO-2017174620-A1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-10-12 | — | — | WO | disclosed |