Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 19/20 | 0.88 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.88 |
| ▸ | MTOR | P42345 | 17/20 | 0.88 |
| ▸ | ATR | Q13535 | 6/20 | 0.88 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.88 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.88 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.88 |
| ▸ | PRKDC | P78527 | 1/20 | 0.88 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29355614 | 0.94 | ATM (1.00) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL17246146 | 0.94 | ATM (1.00) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL30410610 | 0.94 | ATM (1.00) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL22675397 | 0.91 | ATM (0.85) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL17242588 | 0.89 | ATM (1.00) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL17246304 | 0.89 | ATM (1.00) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL17246341 | 0.89 | ATM (1.00) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL17246483 | 0.87 | ATM (1.00) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL20915002 | 0.87 | ATM (0.79) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL17242505 | 0.87 | ATM (1.00) | ATMPIK3CAMTORATRPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017174446-A1 | N,N-DIMETHYL-3-[[5-(3-METHYL-2-OXO-1-TETRAHYDROPYRAN-4-YL-IMIDAZO[4,5-C]QUINOLIN-8-YL)-2-PYRIDYL]OXY]PROPAN-1-AMINE OXIDE AS ATM (ATAXIA TELANGIECTASIA MUTATED) KINASE MODULATOR FOR TREATING CANCER | ASTRAZENECA AB (SE) | 2017-10-12 | — | — | WO | disclosed |