Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 16/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.53 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19460992 | 1.00 | MTOR (0.64) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19631514 | 0.91 | MTOR (0.75) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19629362 | 0.91 | MTOR (0.69) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19460915 | 0.90 | MTOR (0.69) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19479130 | 0.90 | MTOR (0.69) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19457633 | 0.90 | MTOR (0.69) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19457723 | 0.90 | MTOR (0.66) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19460657 | 0.90 | MTOR (0.66) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19460574 | 0.89 | MTOR (0.65) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19460996 | 0.89 | MTOR (0.65) | MTORPIK3CAPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017178591-A1 | 4-(AZETIDIN-1-YL)PYRIMIDINE DERIVATIVES WITH ANTI-MITOTIC AND ANTI-PROLIFERATIVE ACTIVITY | UNIVERSITÄT BASEL (CH) | 2017-10-19 | — | — | WO | disclosed |
| WO-2017178591-A1 | 4-(AZETIDIN-1-YL)PYRIMIDINE DERIVATIVES WITH ANTI-MITOTIC AND ANTI-PROLIFERATIVE ACTIVITY | UNIVERSITÄT BASEL (CH) | 2017-10-19 | — | — | WO | disclosed |
| EP-3231799-A1 | 4-(AZETIDIN-1-YL)PYRIMIDINE DERIVATIVES WITH ANTI-MITOTIC AND ANTI-PROLIFERATIVE ACTIVITY | Universität Basel (CH) | 2017-10-18 | — | — | EP | disclosed |
| EP-3231799-A1 | 4-(AZETIDIN-1-YL)PYRIMIDINE DERIVATIVES WITH ANTI-MITOTIC AND ANTI-PROLIFERATIVE ACTIVITY | Universität Basel (CH) | 2017-10-18 | — | — | EP | disclosed |