Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24531302 | 1.00 | CYP3A4 (0.62) | CYP3A4MAPTCYP2C9CYP2C19POLB | |
| SCHEMBL24239926 | 1.00 | CYP3A4 (0.62) | CYP3A4MAPTCYP2C9CYP2C19POLB | |
| SCHEMBL23618355 | 1.00 | CYP3A4 (0.62) | CYP3A4MAPTCYP2C9CYP2C19POLB | |
| SCHEMBL10082992 | 1.00 | CYP3A4 (0.62) | CYP3A4MAPTCYP2C9CYP2C19POLB | |
| SCHEMBL24531300 | 1.00 | CYP3A4 (0.62) | CYP3A4MAPTCYP2C9CYP2C19POLB | |
| SCHEMBL17235452 | 0.95 | CYP3A4 (0.60) | CYP3A4MAPTCYP2C9CYP2C19POLB | |
| SCHEMBL18769699 | 0.95 | CYP3A4 (0.60) | CYP3A4MAPTCYP2C9CYP2C19POLB | |
| SCHEMBL21919751 | 0.95 | CYP3A4 (0.60) | CYP3A4MAPTCYP2C9CYP2C19POLB | |
| SCHEMBL19477766 | 0.95 | CYP3A4 (0.60) | CYP3A4MAPTCYP2C9CYP2C19POLB | |
| SCHEMBL19501230 | 0.95 | CYP3A4 (0.60) | CYP3A4MAPTCYP2C9CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3443092-A1 | TARGETED NUCLEIC ACID CONJUGATE COMPOSITIONS | Arbutus Biopharma Corporation (CA) | 2019-02-20 | — | — | EP | disclosed |
| WO-2017177326-A1 | TARGETED NUCLEIC ACID CONJUGATE COMPOSITIONS | PROTIVA BIOTHERAPEUTICS, INC. (CA) | 2017-10-19 | — | — | WO | disclosed |