Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 18/20 | 0.46 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.44 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16334497 | 0.92 | IL2 (0.55) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL19464544 | 0.85 | IL2 (0.42) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL16334415 | 0.84 | IL2 (0.56) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL16335085 | 0.83 | IL2 (0.55) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL16335435 | 0.81 | IL2 (0.61) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL17762909 | 0.79 | IL2 (0.55) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL16334408 | 0.78 | IL2 (0.55) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL16335318 | 0.77 | STIM1 (0.54) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL16335014 | 0.77 | STIM1 (0.54) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL16339913 | 0.77 | STIM1 (0.54) | IL2STIM1ORAI1ORAI2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790231-B2 | Chromane and chromene derivatives and their use as CRAC modulators | LUPIN LIMITED (IN) | 2017-10-17 | — | — | US | disclosed |