Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 6/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11920529 | 1.00 | BTK (0.45) | BTKCHRM2CHRM1CHRM3HRH3 | |
| SCHEMBL26999357 | 0.89 | CHRM2 (0.44) | BTKCHRM2CHRM1CHRM3HRH3 | |
| SCHEMBL9651542 | 0.89 | CHRM2 (0.44) | BTKCHRM2CHRM1CHRM3HRH3 | |
| SCHEMBL1139458 | 0.89 | CHRM2 (0.44) | BTKCHRM2CHRM1CHRM3HRH3 | |
| SCHEMBL1296378 | 0.88 | BTK (0.50) | BTKCHRM2CHRM1CHRM3HRH3 | |
| SCHEMBL25762342 | 0.88 | BTK (0.50) | BTKCHRM2CHRM1CHRM3HRH3 | |
| SCHEMBL1690233 | 0.84 | HRH3 (0.49) | BTKCHRM2CHRM1CHRM3HRH3 | |
| SCHEMBL3958434 | 0.82 | CHRM2 (0.48) | BTKCHRM2CHRM1CHRM3HRH3 | |
| SCHEMBL1965621 | 0.82 | CHRM2 (0.48) | BTKCHRM2CHRM1CHRM3HRH3 | |
| SCHEMBL2342365 | 0.82 | CHRM2 (0.48) | BTKCHRM2CHRM1CHRM3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790229-B2 | Bruton's tyrosine kinase inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2017-10-17 | — | — | US | disclosed |