Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28491160 | 1.00 | TSHR (0.68) | TSHRLMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL8437507 | 1.00 | TSHR (0.68) | TSHRLMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL11668939 | 1.00 | TSHR (0.68) | TSHRLMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL11744779 | 1.00 | TSHR (0.68) | TSHRLMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL5820037 | 1.00 | TSHR (0.68) | TSHRLMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL8434344 | 1.00 | TSHR (0.68) | TSHRLMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL27278949 | 0.97 | SMN1; SMN2 (0.67) | TSHRLMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL2360901 | 0.95 | TSHR (0.60) | TSHRLMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL10835848 | 0.95 | TSHR (0.60) | TSHRLMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL11529305 | 0.95 | TSHR (0.60) | TSHRLMNAALDH1A1HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184558-A1 | NOVEL PROMYSALIN ANALOGUES AND METHODS OF USE THEREOF | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-10-26 | — | — | WO | claimed |
| WO-2017184558-A1 | NOVEL PROMYSALIN ANALOGUES AND METHODS OF USE THEREOF | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-10-26 | — | — | WO | disclosed |