Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19462030 | 1.00 | EHMT2 (0.53) | EHMT2DRD4CHRNB4CHRNA3HTR4 | |
| SCHEMBL19476947 | 1.00 | EHMT2 (0.53) | EHMT2DRD4CHRNB4CHRNA3HTR4 | |
| SCHEMBL21644468 | 0.94 | PDPK1 (0.48) | EHMT2DRD4CHRNB4CHRNA3HTR4 | |
| SCHEMBL19462027 | 0.92 | CHRNB4 (0.49) | EHMT2DRD4CHRNB4CHRNA3KDM4E | |
| SCHEMBL6313905 | 0.89 | KDM4E (0.51) | EHMT2HTR4KDM4EGAAMAPT | |
| SCHEMBL19462313 | 0.85 | DRD4 (0.47) | EHMT2DRD4CHRNB4CHRNA3HTR4 | |
| SCHEMBL5704546 | 0.85 | GAA (0.51) | DRD4KDM4EGAAMAPTPDE4B | |
| SCHEMBL19462182 | 0.84 | DRD4 (0.46) | EHMT2DRD4CHRNB4CHRNA3HTR4 | |
| SCHEMBL19476950 | 0.83 | EHMT2 (0.47) | EHMT2DRD4CHRNB4CHRNA3PDPK1 | |
| SCHEMBL5704565 | 0.82 | PDE4B (0.49) | DRD4CHRNB4CHRNA3KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017181177-A1 | AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS | Epizyme, Inc. (US) | 2017-10-19 | — | — | WO | disclosed |