Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.58 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.41 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14754711 | 0.89 | PDE5A (0.51) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL20433793 | 0.89 | PDE5A (0.48) | PDE5ABTKGUCY1A1GUCY1B1 | |
| SCHEMBL29011924 | 0.86 | PDE5A (0.49) | PDE5ABTKGUCY1A1GUCY1B1 | |
| SCHEMBL174461 | 0.83 | PDE5A (0.52) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL19151780 | 0.83 | PDE5A (0.50) | PDE5A | |
| SCHEMBL29219273 | 0.83 | PDE5A (0.49) | PDE5A | |
| SCHEMBL29219198 | 0.83 | PDE5A (0.49) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL22906078 | 0.82 | PDE5A (0.47) | PDE5ABTKGUCY1A1GUCY1B1 | |
| SCHEMBL19312309 | 0.82 | PDE5A (0.49) | PDE5ABTK | |
| SCHEMBL9913932 | 0.81 | PDE5A (0.46) | PDE5ABTKGUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751106-B1 | SUBSTITUTED ANNELLATED PYRIMIDINE AND THE USE THEREOF | BAYER IP GMBH (DE) | 2017-10-18 | — | — | EP | disclosed |