Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19103274 | 0.93 | EGFR (0.53) | EGFR | |
| SCHEMBL19493392 | 0.92 | EGFR (0.57) | EGFRMKNK2 | |
| SCHEMBL19103273 | 0.89 | EGFR (0.61) | EGFR | |
| SCHEMBL19103275 | 0.87 | EGFR (0.48) | EGFRMKNK2 | |
| SCHEMBL19485460 | 0.87 | EGFR (0.58) | EGFR | |
| SCHEMBL19103265 | 0.87 | EGFR (0.58) | EGFR | |
| SCHEMBL19103269 | 0.83 | EGFR (0.57) | EGFR | |
| SCHEMBL19103271 | 0.83 | EGFR (0.44) | EGFR | |
| SCHEMBL19103293 | 0.82 | EGFR (0.51) | EGFR | |
| SCHEMBL30748688 | 0.82 | EGFR (0.63) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796712-B2 | Heteroaryl compounds for kinase inhibition | ARIAD PHARMACEUTICALS, INC. (US) | 2017-10-24 | — | — | US | disclosed |