Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19485973 | 0.81 | GAA (0.58) | GAAALDH1A1LMNAPKMCYP1A2 | |
| SCHEMBL12029057 | 0.80 | GAA (1.00) | GAAALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL3077457 | 0.80 | GAA (1.00) | GAAALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL12028883 | 0.80 | GAA (1.00) | GAAALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL25719625 | 0.79 | GAA (0.58) | GAAALDH1A1CA2CA1CA9 | |
| SCHEMBL14237867 | 0.78 | GAA (0.83) | GAAALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL14237910 | 0.78 | GAA (0.51) | GAAALDH1A1CA2CYP1A2 | |
| SCHEMBL20902102 | 0.78 | GAA (0.51) | GAAALDH1A1CA2CYP1A2 | |
| SCHEMBL23921490 | 0.78 | GAA (0.57) | GAAALDH1A1SMN1; SMN2RECQLKDM4E | |
| SCHEMBL28529745 | 0.77 | GAA (0.53) | GAAALDH1A1LMNAPKMCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796754-B2 | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives | AMBRX, INC. (US) | 2017-10-24 | — | — | US | disclosed |