Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.67 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.65 |
| ▸ | OSBP | P22059 | 3/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.61 |
| ▸ | RORC | P51449 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.61 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.61 |
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | GBA1 | P04062 | 2/20 | 0.55 |
| ▸ | UGCG | Q16739 | 2/20 | 0.55 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.55 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.55 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11948053 | 0.98 | POLA1 (0.65) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL15702066 | 0.98 | POLA1 (0.65) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL14963546 | 0.96 | POLA1 (0.65) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL20851995 | 0.96 | POLA1 (0.65) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL14031535 | 0.96 | POLA1 (0.65) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL26032426 | 0.95 | POLA1 (0.66) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL26032453 | 0.94 | POLA1 (0.65) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL14258542 | 0.94 | POLA1 (0.61) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL14258526 | 0.94 | POLA1 (0.62) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL14258523 | 0.94 | POLA1 (0.62) | POLA1CYP46A1OSBPUSP2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000754-B2 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2018-06-19 | — | — | US | disclosed |
| US-20170298355-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) | BANK OF AMERICA, N.A. | 2017-10-19 | — | — | US | disclosed |