Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | PRKX | P51817 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18809970 | 1.00 | EPHX2 (0.50) | EPHX2ROCK2ROCK1PKN2TSHR | |
| SCHEMBL18809737 | 1.00 | EPHX2 (0.50) | EPHX2ROCK2ROCK1PKN2TSHR | |
| SCHEMBL19489363 | 1.00 | EPHX2 (0.50) | EPHX2ROCK2ROCK1PKN2TSHR | |
| SCHEMBL18431022 | 1.00 | EPHX2 (0.50) | EPHX2ROCK2ROCK1PKN2TSHR | |
| SCHEMBL18947254 | 0.98 | EPHX2 (0.51) | EPHX2ROCK2ROCK1PKN2TSHR | |
| SCHEMBL18431034 | 0.98 | EPHX2 (0.51) | EPHX2ROCK2ROCK1PKN2TSHR | |
| SCHEMBL18947232 | 0.98 | EPHX2 (0.51) | EPHX2ROCK2ROCK1PKN2TSHR | |
| SCHEMBL19489277 | 0.98 | EPHX2 (0.48) | EPHX2ROCK2ROCK1PKN2TSHR | |
| SCHEMBL18431023 | 0.97 | EPHX2 (0.52) | EPHX2TSHRCYP2D6HTTHRH3 | |
| SCHEMBL18431059 | 0.97 | EPHX2 (0.52) | EPHX2TSHRCYP2D6HTTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3231798-A1 | THIAZOLE INTERMEDIATES USEFUL IN THE PREPARATION OF RAF KINASE INHIBITORS | Sunesis Pharmaceuticals, Inc. (US) | 2017-10-18 | — | — | EP | disclosed |