Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 20/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19493599 | 0.88 | MAPK1 (0.41) | MAPK1 | |
| SCHEMBL19494134 | 0.85 | MAPK1 (0.41) | MAPK1 | |
| SCHEMBL19494150 | 0.81 | MAPK1 (0.51) | MAPK1 | |
| SCHEMBL19494135 | 0.80 | MAPK1 (0.36) | MAPK1 | |
| SCHEMBL7702341 | 0.77 | ADORA2A (0.33) | — | |
| SCHEMBL16830112 | 0.73 | GRM4 (0.30) | — | |
| SCHEMBL16516791 | 0.73 | GRM4 (0.30) | — | |
| SCHEMBL30596252 | 0.73 | GRM4 (0.30) | — | |
| SCHEMBL16964858 | 0.69 | MAPK1 (0.46) | MAPK1 | |
| SCHEMBL31144193 | 0.69 | MAPK1 (0.46) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900223-B1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2017-10-25 | — | — | EP | disclosed |