Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.69 |
| ▸ | KDR | P35968 | 6/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | PRKDC | P78527 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14242000 | 0.90 | SYK (0.65) | SYKKDRKCNH2 | |
| SCHEMBL14242587 | 0.88 | SYK (0.74) | SYKKDRKCNH2 | |
| SCHEMBL14242041 | 0.87 | SYK (0.71) | SYKKDRKCNH2 | |
| SCHEMBL14242146 | 0.85 | SYK (0.90) | SYKKDRKCNH2 | |
| SCHEMBL19496229 | 0.84 | SYK (0.73) | SYKKDRKCNH2PRKDC | |
| SCHEMBL14242048 | 0.84 | SYK (0.76) | SYKKDRKCNH2 | |
| SCHEMBL14242585 | 0.84 | SYK (0.67) | SYKKDRKCNH2 | |
| SCHEMBL19495636 | 0.84 | SYK (0.51) | SYKKDRKCNH2 | |
| SCHEMBL19495898 | 0.83 | SYK (0.76) | SYKKDRKCNH2 | |
| SCHEMBL19495669 | 0.82 | SYK (0.52) | SYKKDRKCNH2PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2718293-B1 | SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2017-10-25 | — | — | EP | disclosed |