Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 4/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15656277 | 1.00 | EPHA2 (0.39) | EPHA2ERBB2EPHB4MALT1USP30 | |
| SCHEMBL14242319 | 1.00 | EPHA2 (0.39) | EPHA2ERBB2EPHB4MALT1USP30 | |
| SCHEMBL15656279 | 1.00 | EPHA2 (0.39) | EPHA2ERBB2EPHB4MALT1USP30 | |
| SCHEMBL12527149 | 0.85 | EPHA2 (0.44) | EPHA2ERBB2EPHB4MALT1 | |
| SCHEMBL15656132 | 0.85 | EPHA2 (0.44) | EPHA2ERBB2EPHB4MALT1 | |
| SCHEMBL15775171 | 0.85 | MALT1 (0.36) | EPHA2ERBB2EPHB4MALT1USP30 | |
| SCHEMBL15774924 | 0.85 | MALT1 (0.36) | EPHA2ERBB2EPHB4MALT1USP30 | |
| SCHEMBL12527236 | 0.85 | EPHA2 (0.44) | EPHA2ERBB2EPHB4MALT1 | |
| SCHEMBL15774886 | 0.85 | MALT1 (0.36) | EPHA2ERBB2EPHB4MALT1USP30 | |
| SCHEMBL15774925 | 0.85 | MALT1 (0.36) | EPHA2ERBB2EPHB4MALT1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2718293-B1 | SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2017-10-25 | — | — | EP | disclosed |