Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.37 |
| ▸ | MMP7 | P09237 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16426900 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AHSD11B1POLBCHRM2 | |
| SCHEMBL16426901 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AHSD11B1POLBCHRM2 | |
| SCHEMBL16427605 | 0.86 | KMT2A (0.53) | KMT2AHSD11B1CHRM2CHRM1ALDH1A1 | |
| SCHEMBL16427606 | 0.86 | KMT2A (0.53) | KMT2AHSD11B1CHRM2CHRM1ALDH1A1 | |
| SCHEMBL18603267 | 0.85 | CHRM2 (0.38) | SMN1; SMN2HSD11B1CHRM2CHRM1MMP2 | |
| SCHEMBL20202072 | 0.85 | CHRM2 (0.38) | SMN1; SMN2HSD11B1CHRM2CHRM1MMP2 | |
| SCHEMBL20981967 | 0.85 | CHRM2 (0.38) | SMN1; SMN2HSD11B1CHRM2CHRM1MMP2 | |
| SCHEMBL17102246 | 0.85 | CHRM2 (0.38) | SMN1; SMN2HSD11B1CHRM2CHRM1MMP2 | |
| SCHEMBL17121095 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AHSD11B1POLBCHRM2 | |
| SCHEMBL19947558 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1POLBMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027601-B1 | SYK INHIBITORS | GILEAD SCIENCES INC (US) | 2017-10-25 | — | — | EP | disclosed |