Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 16/20 | 0.61 |
| ▸ | EED | O75530 | 2/20 | 0.53 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.53 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.53 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.53 |
| ▸ | EZH1 | Q92800 | 4/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.49 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.49 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19503266 | 0.95 | EZH2 (0.69) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19503285 | 0.93 | EZH2 (0.69) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19503267 | 0.87 | EZH2 (0.71) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL20991857 | 0.86 | EZH2 (0.53) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19503505 | 0.84 | EZH2 (0.81) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL20991849 | 0.84 | EZH2 (0.67) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19503275 | 0.83 | EZH2 (0.55) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19503268 | 0.81 | EZH2 (0.69) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19503236 | 0.79 | EZH2 (0.84) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL23863678 | 0.79 | EZH1 (0.64) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184999-A1 | EZH2 INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-10-26 | — | — | WO | disclosed |