SCHEMBL19503849

CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCN(C(=O)CN=[N+]=[N-])CC5)CSc5ccccc5)c([S+]([O-])C(F)(F)F)c4)cc3)CC2)C1

nearest known ligand 0.70

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	BCL2L1	Q07817	18/20	0.70

▸	BCL2	P10415	14/20	0.70

▸	BAD	Q92934	4/20	0.70

▸	BCL2L2	Q92843	2/20	0.70

▸	BCL2L11	O43521	1/20	0.70

▸	CYP2C9	P11712	1/20	0.70

▸	MCL1	Q07820	1/20	0.70

▸	ASPH	Q12797	1/20	0.70

▸	VHL	P40337	2/20	0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL21896505	0.95	BCL2L1 (0.69)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19475758	0.92	BCL2L1 (0.83)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19475755	0.92	BCL2L1 (0.83)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19503614	0.87	BCL2L1 (0.81)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL20956661	0.87	BCL2L1 (0.81)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19475889	0.84	BCL2L1 (0.91)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19475888	0.84	BCL2L1 (0.91)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL21896504	0.84	BCL2L1 (0.75)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL5522380	0.83	BCL2L1 (0.87)	BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19145093	0.83	BCL2L1 (0.93)	BCL2L1BCL2BADBCL2L2BCL2L11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017184995-A1	COMPOUNDS THAT INDUCE DEGRADATION OF ANTI-APOPTOTIC BCL-2 FAMILY PROTEINS AND THE USES THEREOF	BIOVENTURES, LLC (US)	2017-10-26	—	—	WO	disclosed