Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 3/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | KLK1 | P06870 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19475329 | 0.90 | HTT (0.36) | HTTTDP1NPSR1ALDH1A1TSHR | |
| SCHEMBL19475330 | 0.90 | HTT (0.36) | HTTTDP1NPSR1ALDH1A1TSHR | |
| SCHEMBL19506084 | 0.90 | KDM4E (0.35) | HTTTDP1NPSR1ALDH1A1TSHR | |
| SCHEMBL19506080 | 0.84 | KMT2A (0.33) | ALDH1A1TSHRGAAKMT2AMEN1 | |
| SCHEMBL19505791 | 0.83 | NPSR1 (0.36) | HTTTDP1NPSR1ALDH1A1TSHR | |
| SCHEMBL19475313 | 0.80 | KDM4E (0.36) | HTTTDP1NPSR1ALDH1A1TSHR | |
| SCHEMBL19475315 | 0.80 | KDM4E (0.36) | HTTTDP1NPSR1ALDH1A1TSHR | |
| SCHEMBL19505796 | 0.79 | MEN1 (0.34) | KMT2ALMNAMEN1 | |
| SCHEMBL19505779 | 0.78 | MEN1 (0.42) | NPSR1ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL19506177 | 0.77 | TSHR (0.38) | HTTTDP1NPSR1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184558-A1 | NOVEL PROMYSALIN ANALOGUES AND METHODS OF USE THEREOF | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-10-26 | — | — | WO | disclosed |