Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | MELK | Q14680 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19507770 | 0.97 | EGFR (0.47) | EGFRJAK3MELKCSNK2A2CSNK2B | |
| SCHEMBL19507717 | 0.90 | CDC7 (0.47) | EGFRJAK3MELKCSNK2A2CSNK2B | |
| SCHEMBL19507718 | 0.84 | HDAC2 (0.43) | EGFRJAK3MELKCSNK2A1ABL1 | |
| SCHEMBL19507714 | 0.84 | HDAC2 (0.43) | EGFRJAK3MELKCSNK2A2CSNK2B | |
| SCHEMBL19507643 | 0.84 | ERBB2 (0.53) | EGFRABL1MAPTCDC7ROCK2 | |
| SCHEMBL19507769 | 0.83 | EGFR (0.52) | EGFRABL1CDK1PRKCABRAF | |
| SCHEMBL19475730 | 0.82 | PIK3CG (0.44) | EGFRJAK3MEN1KMT2ABRAF | |
| SCHEMBL19507784 | 0.79 | FYN (0.42) | JAK3BRAF | |
| SCHEMBL19507935 | 0.79 | FYN (0.48) | EGFRABL1BRAFROCK2 | |
| SCHEMBL8124429 | 0.78 | EGFR (0.53) | EGFRJAK3MELKABL1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184775-A1 | ERBB INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-26 | — | — | WO | disclosed |