⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19152803 | 0.76 | — | — | |
| SCHEMBL575908 | 0.69 | — | — | |
| Fluoride SCHEMBL775647 | 0.67 | — | — | |
| SCHEMBL2524103 | 0.65 | — | — | |
| SCHEMBL3396995 | 0.65 | — | — | |
| SCHEMBL11297283 | 0.65 | — | — | |
| SCHEMBL13347878 | 0.65 | TSHR (0.33) | — | |
| Dimethylamine SCHEMBL6419423 | 0.64 | — | — | |
| Dimethylamine SCHEMBL8951940 | 0.61 | — | — | |
| SCHEMBL12085988 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230026968-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2023-01-26 | — | — | US | disclosed |
| US-20220213486-A1 | COMPLEMENT COMPONENT iRNA COMPOSITIONS AND METHODS OF USE THEREOF | ALNYLAM PHARMACEUTICALS, INC. | 2022-07-07 | — | — | US | disclosed |
| US-20210169915-A1 | POLYNUCLEOTIDE AGENTS TARGETING ANGIOTENSINOGEN (AGT) AND METHODS OF USE THEREOF | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2021-06-10 | — | — | US | disclosed |
| US-10478500-B2 | Compositions and methods for inhibition of HAO1 (Hydroxyacid Oxidase 1 (Glycolate Oxidase)) gene expression | ALNYLAM PHARMACEUTICALS, INC. (US) | 2019-11-19 | — | — | US | disclosed |
| US-20180169129-A1 | POLYNUCLEOTIDE AGENTS TARGETING ANGIOTENSINOGEN (AGT) AND METHODS OF USE THEREOF | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2018-06-21 | — | — | US | disclosed |
| US-20170304446-A1 | Compositions and Methods for Inhibition of HAO1 (Hydroxyacid Oxidase 1 (Glycolate Oxidase)) Gene Expression | BANK OF AMERICA, N.A. | 2017-10-26 | — | — | US | disclosed |