Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 17/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 17/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 16/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 16/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 16/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 16/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 16/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 16/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 16/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19522202 | 0.99 | HDAC1 (0.46) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL19522208 | 0.99 | HDAC1 (0.46) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL18357166 | 0.93 | HDAC1 (0.45) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL18357098 | 0.92 | HDAC1 (0.46) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL18357097 | 0.92 | HDAC1 (0.46) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL19522205 | 0.91 | NAMPT (0.43) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL18357006 | 0.90 | NAMPT (0.42) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL18357074 | 0.86 | SNCA (0.40) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL18357099 | 0.86 | NAMPT (0.41) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL18356839 | 0.86 | EP300 (0.41) | HDAC1HDAC6HDAC3HDAC2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10040799-B2 | Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity | NORTHWESTERN UNIVERSITY (US) | 2018-08-07 | — | — | US | disclosed |
| US-20180037586-A1 | SUBSTITUTED 4-METHYL-PYRROLO[1,2-A]PYRIMIDINE-8-CARBOXAMIDE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | NORTHWESTERN UNIVERSITY (US) | 2018-02-08 | — | — | US | disclosed |
| US-9802942-B2 | Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity | NORTHWESTERN UNIVERSITY (US) | 2017-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10040799-B2 | Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity | GBA1, GBA2, GBA3 | HDAC1 683/4885HDAC6 663/4885HDAC3 1821/4885 |
| US-20180037586-A1 | SUBSTITUTED 4-METHYL-PYRROLO[1,2-A]PYRIMIDINE-8-CARBOXAMIDE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | GBA1, GBA2, GBA3 | HDAC1 683/4885HDAC6 663/4885HDAC3 1821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.