Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 2/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 2/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18356613 | 0.95 | NAMPT (0.37) | NAMPTSNCAPIK3CDPIK3CAEP300 | |
| SCHEMBL19522203 | 0.91 | NAMPT (0.39) | NAMPTEP300 | |
| SCHEMBL19522209 | 0.91 | EP300 (0.39) | NAMPTEP300 | |
| SCHEMBL19522204 | 0.91 | EP300 (0.39) | NAMPTEP300 | |
| SCHEMBL18357099 | 0.86 | NAMPT (0.41) | NAMPTEP300 | |
| SCHEMBL18357100 | 0.86 | EP300 (0.41) | NAMPTEP300 | |
| SCHEMBL18356839 | 0.86 | EP300 (0.41) | NAMPTEP300 | |
| SCHEMBL21013143 | 0.85 | NAMPT (0.36) | NAMPTSNCAPIK3CDPIK3CAEP300 | |
| SCHEMBL19522210 | 0.83 | NAMPT (0.40) | NAMPTSNCAPIK3CDPIK3CARXFP1 | |
| SCHEMBL19522212 | 0.83 | NAMPT (0.40) | NAMPTSNCAPIK3CDPIK3CARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10040799-B2 | Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity | NORTHWESTERN UNIVERSITY (US) | 2018-08-07 | — | — | US | disclosed |
| US-20180037586-A1 | SUBSTITUTED 4-METHYL-PYRROLO[1,2-A]PYRIMIDINE-8-CARBOXAMIDE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | NORTHWESTERN UNIVERSITY (US) | 2018-02-08 | — | — | US | disclosed |
| US-9802942-B2 | Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity | NORTHWESTERN UNIVERSITY (US) | 2017-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10040799-B2 | Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity | GBA1, GBA2, GBA3 | NAMPT 519/4885SNCA 85/4885PIK3CD 767/4885 |
| US-20180037586-A1 | SUBSTITUTED 4-METHYL-PYRROLO[1,2-A]PYRIMIDINE-8-CARBOXAMIDE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | GBA1, GBA2, GBA3 | NAMPT 519/4885SNCA 85/4885PIK3CD 767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.