Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.64 |
| ▸ | DRD4 | P21917 | 1/20 | 0.64 |
| ▸ | DRD5 | P21918 | 1/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.64 |
| ▸ | HTR1D | P28221 | 1/20 | 0.64 |
| ▸ | HTR1B | P28222 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | TSPO | P30536 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | HRH1 | P35367 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6491975 | 0.94 | TMEM97 (0.56) | TMEM97HTR1ACHRM5ADRA2AADRA2B | |
| SCHEMBL19540968 | 0.88 | TMEM97 (0.56) | TMEM97HTR1ACHRM5ADRA2AADRA2B | |
| SCHEMBL19540912 | 0.87 | TMEM97 (0.64) | TMEM97HTR1ACHRM5ADRA2AADRA2B | |
| SCHEMBL19540843 | 0.87 | TMEM97 (0.61) | TMEM97HTR1ACHRM5ADRA2AADRA2B | |
| SCHEMBL19521052 | 0.82 | TMEM97 (0.85) | TMEM97HTR1ACHRM5ADRA2AADRA2B | |
| SCHEMBL19521054 | 0.81 | TMEM97 (0.58) | TMEM97HTR1ACHRM5ADRA2AADRA2B | |
| SCHEMBL19540915 | 0.81 | TMEM97 (0.57) | TMEM97HTR1ACHRM5ADRA2AADRA2B | |
| SCHEMBL22004629 | 0.81 | TMEM97 (0.44) | TMEM97HTR1ACHRM5ADRA2AADRA2B | |
| SCHEMBL19521146 | 0.81 | TMEM97 (0.77) | TMEM97HTR1ACHRM5ADRA2AADRA2B | |
| SCHEMBL19521109 | 0.81 | TMEM97 (0.77) | TMEM97HTR1ACHRM5ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017190107-A1 | SIGMA RECEPTOR BINDERS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-11-02 | — | — | WO | disclosed |