Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 3/20 | 0.66 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.66 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.66 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.66 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.66 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.66 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.66 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.66 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.66 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | OSBP | P22059 | 1/20 | 0.58 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119076 | 0.93 | EPHA2 (0.69) | EPHA2GPBAR1HSD17B10TDP1AKR1B10 | |
| SCHEMBL28514223 | 0.91 | EPHA2 (0.67) | EPHA2GPBAR1HSD17B10TDP1AKR1B10 | |
| SCHEMBL2155405 | 0.91 | EPHA2 (0.67) | EPHA2GPBAR1HSD17B10TDP1AKR1B10 | |
| SCHEMBL28088042 | 0.90 | EPHA2 (0.67) | EPHA2GPBAR1HSD17B10TDP1AKR1B10 | |
| SCHEMBL27635313 | 0.90 | EPHA2 (0.67) | EPHA2GPBAR1HSD17B10TDP1AKR1B10 | |
| SCHEMBL14676689 | 0.90 | CYP2D6 (0.71) | EPHA2GPBAR1HSD17B10TDP1AKR1B10 | |
| SCHEMBL28898907 | 0.90 | CYP2D6 (0.71) | EPHA2GPBAR1HSD17B10TDP1AKR1B10 | |
| SCHEMBL4739596 | 0.90 | CYP2D6 (0.71) | EPHA2GPBAR1HSD17B10TDP1AKR1B10 | |
| SCHEMBL288945 | 0.90 | CYP2D6 (0.71) | EPHA2GPBAR1HSD17B10TDP1AKR1B10 | |
| SCHEMBL135273 | 0.90 | CYP2D6 (0.71) | EPHA2GPBAR1HSD17B10TDP1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2506856-B1 | AMINOSTEROID COMPOUNDS FOR TOPIC LOCAL APPLICATION FOR SKIN-MUCOSA DECOLONISATION OF STAPHYLOCOCCUS AUREUS | ASSIST PUBLIQUE HOPITAUX DE MARSEILLE (FR) | 2019-01-02 | — | — | EP | claimed |
| US-9700051-B2 | Use of squalamine or analogue as a disinfecting agent | Assistance Publique—Hopitaux de Marseille (FR) | 2017-07-11 | — | — | US | claimed |
| US-20150005274-A1 | USE OF SQUALAMINE OR ANALOGUE AS A DISINFECTING AGENT | ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE (FR) | 2015-01-01 | — | — | US | claimed |
| EP-2802214-A1 | USE OF SQUALAMINE OR ANALOGUE AS A DISINFECTING AGENT | Assistance Publique Hôpitaux de Marseille (FR) | 2014-11-19 | — | — | EP | claimed |
| WO-2013104849-A1 | USE OF SQUALAMINE OR ANALOGUE AS A DISINFECTING AGENT | ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE (FR) | 2013-07-18 | — | — | WO | claimed |
| EP-2506856-A1 | AMINOSTEROID COMPOUNDS FOR TOPIC LOCAL APPLICATION FOR SKIN-MUCOSA DECOLONISATION OF STAPHYLOCOCCUS AUREUS | Assistance Publique Hôpitaux de Marseille (FR) | 2012-10-10 | — | — | EP | claimed |
| WO-2011067501-A1 | LOCAL TOPICAL APPLICATION AMINOSTEROID COMPOUNDS FOR MUCOUS/CUTANEOUS DECOLONIZATION OF STAPHYLOCOCCUS AUREUS | ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE (FR) | 2011-06-09 | — | — | WO | claimed |
| EP-2506856-B1 | AMINOSTEROID COMPOUNDS FOR TOPIC LOCAL APPLICATION FOR SKIN-MUCOSA DECOLONISATION OF STAPHYLOCOCCUS AUREUS | ASSIST PUBLIQUE HOPITAUX DE MARSEILLE (FR) | 2019-01-02 | — | — | EP | disclosed |
| US-9700051-B2 | Use of squalamine or analogue as a disinfecting agent | Assistance Publique—Hopitaux de Marseille (FR) | 2017-07-11 | — | — | US | disclosed |
| US-20150005274-A1 | USE OF SQUALAMINE OR ANALOGUE AS A DISINFECTING AGENT | ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE (FR) | 2015-01-01 | — | — | US | disclosed |
| EP-2802214-A1 | USE OF SQUALAMINE OR ANALOGUE AS A DISINFECTING AGENT | Assistance Publique Hôpitaux de Marseille (FR) | 2014-11-19 | — | — | EP | disclosed |
| WO-2013104849-A1 | USE OF SQUALAMINE OR ANALOGUE AS A DISINFECTING AGENT | ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE (FR) | 2013-07-18 | — | — | WO | disclosed |
| EP-2506856-A1 | AMINOSTEROID COMPOUNDS FOR TOPIC LOCAL APPLICATION FOR SKIN-MUCOSA DECOLONISATION OF STAPHYLOCOCCUS AUREUS | Assistance Publique Hôpitaux de Marseille (FR) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011067501-A1 | LOCAL TOPICAL APPLICATION AMINOSTEROID COMPOUNDS FOR MUCOUS/CUTANEOUS DECOLONIZATION OF STAPHYLOCOCCUS AUREUS | ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE (FR) | 2011-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150005274-A1 | USE OF SQUALAMINE OR ANALOGUE AS A DISINFECTING AGENT | SQLE, SHARPIN, IL5 | EPHA2 4417/4885GPBAR1 1876/4885HSD17B10 535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.