Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 20/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 20/20 | 0.62 |
| ▸ | WNT1 | P04628 | 12/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19546592 | 0.91 | GSK3B (0.65) | GSK3BDYRK1AWNT1 | |
| SCHEMBL19546742 | 0.90 | GSK3B (0.62) | GSK3BDYRK1AWNT1 | |
| SCHEMBL23916732 | 0.89 | GSK3B (0.61) | GSK3BDYRK1AWNT1 | |
| SCHEMBL19547057 | 0.84 | DYRK1A (0.82) | GSK3BDYRK1AWNT1 | |
| SCHEMBL20030392 | 0.82 | GSK3B (0.72) | GSK3BDYRK1AWNT1 | |
| SCHEMBL19546743 | 0.81 | DYRK1A (0.64) | GSK3BDYRK1AWNT1 | |
| SCHEMBL23916048 | 0.81 | DYRK1A (0.61) | GSK3BDYRK1AWNT1 | |
| SCHEMBL23916060 | 0.81 | DYRK1A (0.62) | GSK3BDYRK1AWNT1 | |
| SCHEMBL23916242 | 0.81 | DYRK1A (0.60) | GSK3BDYRK1AWNT1 | |
| SCHEMBL24219514 | 0.80 | GSK3B (0.81) | GSK3BDYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |
| WO-2017189829-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED, LLC (US) | 2017-11-02 | — | — | WO | disclosed |