Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.81 |
| ▸ | JAK2 | O60674 | 17/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19547456 | 0.90 | NTRK1 (0.83) | NTRK1JAK2 | |
| SCHEMBL2693141 | 0.90 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL2693143 | 0.90 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL19547348 | 0.88 | NTRK1 (0.81) | NTRK1JAK2 | |
| SCHEMBL19547341 | 0.88 | NTRK1 (0.81) | NTRK1JAK2 | |
| Hydrochloric Acid SCHEMBL933542 | 0.86 | NTRK1 (0.88) | NTRK1JAK2 | |
| Hydrochloric Acid SCHEMBL933544 | 0.86 | NTRK1 (0.88) | NTRK1JAK2 | |
| SCHEMBL2692531 | 0.85 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL2692528 | 0.85 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL19547446 | 0.85 | NTRK1 (0.76) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451812-B1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2017-11-08 | — | — | EP | claimed |