Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 17/20 | 0.76 |
| ▸ | BCL2 | P10415 | 16/20 | 0.76 |
| ▸ | BCL2L2 | Q92843 | 2/20 | 0.76 |
| ▸ | BAD | Q92934 | 4/20 | 0.66 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.66 |
| ▸ | ASPH | Q12797 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1958119 | 0.96 | BCL2L1 (0.75) | BCL2L1BCL2BCL2L2BADBCL2L11 | |
| SCHEMBL4735907 | 0.96 | BCL2 (0.70) | BCL2L1BCL2BCL2L2BADBCL2L11 | |
| SCHEMBL19244593 | 0.92 | BCL2 (0.76) | BCL2L1BCL2BCL2L2BADBCL2L11 | |
| SCHEMBL1954118 | 0.92 | BCL2 (0.69) | BCL2L1BCL2BCL2L2BADBCL2L11 | |
| SCHEMBL4735633 | 0.91 | BCL2L1 (0.80) | BCL2L1BCL2BCL2L2BADBCL2L11 | |
| SCHEMBL1958117 | 0.89 | BCL2L1 (0.86) | BCL2L1BCL2BCL2L2BADBCL2L11 | |
| SCHEMBL1954744 | 0.89 | BCL2L1 (0.86) | BCL2L1BCL2BCL2L2BADBCL2L11 | |
| SCHEMBL1954932 | 0.87 | BCL2L1 (0.93) | BCL2L1BCL2BCL2L2BADBCL2L11 | |
| SCHEMBL4735659 | 0.87 | BCL2 (0.73) | BCL2L1BCL2BCL2L2BADBCL2L11 | |
| SCHEMBL2081160 | 0.87 | BCL2L1 (1.00) | BCL2L1BCL2BCL2L2BADBCL2L11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2506853-A1 | COMBINATION THERAPY FOR TREATING CANCER AND DIAGNOSTIC ASSAYS FOR USE THEREIN | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068863-A1 | COMBINATION THERAPY FOR TREATING CANCER AND DIAGNOSTIC ASSAYS FOR USE THEREIN | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |
| WO-2008064116-A2 | METHOD OF PREVENTING OR TREATING ORGAN, HEMATOPOIETIC STEM CELL OR BONE MARROW TRANSPLANT REJECTION | ABBOTT LABORATORIES (US) | 2008-05-29 | — | — | WO | disclosed |