SCHEMBL19549669

SCHEMBL19549669

COc1cccc(-c2cccc(-c3nc4c(s3)CNCC4)c2C)c1

nearest known ligand 0.77

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CD274 Q9NZQ7 15/20 0.77
PDCD1 Q15116 13/20 0.77
TLR9 Q9NR96 1/20 0.39
TLR8 Q9NR97 1/20 0.39
TLR7 Q9NYK1 1/20 0.39
MAPT P10636 1/20 0.38
NFKB1 P19838 1/20 0.38
RAB9A P51151 1/20 0.38
NFKB2 Q00653 1/20 0.38
RELA Q04206 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19549760 0.93 CD274 (0.71) CD274PDCD1TLR9TLR8TLR7
SCHEMBL19549692 0.89 CD274 (0.82) CD274PDCD1
SCHEMBL15933628 0.88 CD274 (0.59) CD274PDCD1TLR9TLR8TLR7
SCHEMBL19549686 0.87 CD274 (1.00) CD274PDCD1
SCHEMBL19549711 0.87 CD274 (0.65) CD274PDCD1TLR9TLR8TLR7
SCHEMBL19549722 0.85 PDCD1 (0.82) CD274PDCD1
SCHEMBL19549793 0.85 CD274 (1.00) CD274PDCD1TLR9TLR8TLR7
SCHEMBL19549685 0.81 PDCD1 (0.65) CD274PDCD1TLR9TLR8TLR7
SCHEMBL19549679 0.79 CD274 (0.62) CD274PDCD1TLR9TLR8TLR7
SCHEMBL19549737 0.79 PDCD1 (1.00) CD274PDCD1TLR9TLR8TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11608337-B2 Heterocyclic compounds as immunomodulators INCYTE CORPORATION (US) 2023-03-21 US claimed
EP-3452476-B1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORP (US) 2021-12-15 EP claimed
EP-3452476-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS Incyte Holdings Corporation (US) 2019-03-13 EP claimed
US-20190071439-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORPORATION 2019-03-07 US claimed
WO-2017192961-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORPORATION (US) 2017-11-09 WO claimed
US-20170320875-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORPORATION 2017-11-09 US claimed
US-20230192689-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORPORATION 2023-06-22 US disclosed
US-20230192689-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORPORATION 2023-06-22 US disclosed
US-20230192689-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORPORATION 2023-06-22 US disclosed
US-11608337-B2 Heterocyclic compounds as immunomodulators INCYTE CORPORATION (US) 2023-03-21 US disclosed
US-20220168268-A1 SMALL-MOLECULE INHIBITOR OF PD-1/PD-L1, PHARMACEUTICAL COMPOSITION THEREOF WITH PD-L1 ANTIBODY, AND APPLICATION OF SAME GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD. (CN) 2022-06-02 US disclosed
EP-3943083-A1 SMALL-MOLECULE INHIBITOR OF PD-1/PD-L1, PHARMACEUTICAL COMPOSITION THEREOF WITH PD-L1 ANTIBODY, AND APPLICATION OF SAME Guangzhou Maxinovel Pharmaceuticals Co., Ltd. (CN) 2022-01-26 EP disclosed
EP-3452476-B1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORP (US) 2021-12-15 EP disclosed
US-20200172541-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORPORATION 2020-06-04 US disclosed
US-20190071439-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORPORATION 2019-03-07 US disclosed
US-20190071439-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORPORATION 2019-03-07 US disclosed
WO-2017192961-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORPORATION (US) 2017-11-09 WO disclosed
US-20170320875-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORPORATION 2017-11-09 US disclosed
US-20170320875-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORPORATION 2017-11-09 US disclosed
US-20170320875-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS INCYTE CORPORATION 2017-11-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230192689-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS CD74, IL2, ICOS CD274 88/4885PDCD1 157/4885TLR9 112/4885
US-20190071439-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS CD74, IL2, ICOS CD274 88/4885PDCD1 157/4885TLR9 112/4885
US-20220168268-A1 SMALL-MOLECULE INHIBITOR OF PD-1/PD-L1, PHARMACEUTICAL COMPOSITION THEREOF WITH PD-L1 ANTIBODY, AND APPLICATION OF SAME PDCD1, PDCD1LG2, CD274 CD274 3/4885PDCD1 1/4885TLR9 1832/4885
US-20170320875-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS CD74, IL2, ICOS CD274 88/4885PDCD1 157/4885TLR9 112/4885
US-20200172541-A1 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS CD74, IL2, ICOS CD274 88/4885PDCD1 157/4885TLR9 112/4885
US-11608337-B2 Heterocyclic compounds as immunomodulators CD74, IL2, ICOS CD274 88/4885PDCD1 157/4885TLR9 112/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.