Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 3/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | IDH2 | P48735 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1955107 | 1.00 | EEF2K (0.47) | EEF2KKCNA5MAPTIDH2POLB | |
| SCHEMBL12971090 | 0.97 | EEF2K (0.47) | EEF2KKCNA5MAPTIDH2POLB | |
| SCHEMBL12971089 | 0.97 | EEF2K (0.47) | EEF2KKCNA5MAPTIDH2POLB | |
| SCHEMBL1955103 | 0.97 | EEF2K (0.47) | EEF2KKCNA5MAPTIDH2POLB | |
| Potassium Ion SCHEMBL1951374 | 0.96 | EEF2K (0.43) | EEF2KKCNA5MAPTIDH2POLB | |
| Potassium Ion SCHEMBL1951375 | 0.96 | EEF2K (0.43) | EEF2KKCNA5MAPTIDH2POLB | |
| Potassium Ion SCHEMBL1951377 | 0.96 | EEF2K (0.43) | EEF2KKCNA5MAPTIDH2POLB | |
| SCHEMBL12577360 | 0.95 | EEF2K (0.43) | EEF2KKCNA5MAPTIDH2POLB | |
| SCHEMBL12577632 | 0.93 | EEF2K (0.43) | EEF2KKCNA5MAPTIDH2POLB | |
| SCHEMBL12577634 | 0.91 | EEF2K (0.41) | EEF2KKCNA5MAPTIDH2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507210-B1 | CYCLOHEXANE DERIVATIVES AS INHIBITORS OF ACETYL-COA CARBOXYLASE (ACC) | NOVARTIS AG (CH) | 2015-04-08 | — | — | EP | disclosed |
| US-8394858-B2 | Cyclohexane derivatives and uses thereof | NOVARTIS AG (CH) | 2013-03-12 | — | — | US | disclosed |
| EP-2507210-A1 | CYCLOHEXANE DERIVATIVES AS INHIBITORS OF ACETYL-COA CARBOXYLASE (ACC) | Novartis AG (CH) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011067306-A1 | CYCLOHEXANE DERIVATIVES AS INHIBITORS OF ACETYL-COA CARBOXYLASE (ACC) | NOVARTIS AG (CH) | 2011-06-09 | — | — | WO | disclosed |