Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19559701 | 0.90 | PPARG (0.51) | PPARGMCL1FFAR1CYP2C9 | |
| SCHEMBL19559756 | 0.85 | PPARG (0.52) | PPARGFFAR1ADRB2ADRB3ADRB1 | |
| SCHEMBL19217776 | 0.85 | PPARG (0.52) | PPARGFFAR1ADRB2ADRB3ADRB1 | |
| SCHEMBL19559736 | 0.84 | SCN4A (0.42) | PPARGMCL1FFAR1ADRB2ADRB3 | |
| SCHEMBL6928451 | 0.83 | PPARG (0.58) | PPARGFFAR1CYP2C9 | |
| SCHEMBL21504741 | 0.83 | PPARG (0.58) | PPARGFFAR1CYP2C9 | |
| SCHEMBL6928167 | 0.83 | PPARG (0.58) | PPARGFFAR1CYP2C9 | |
| SCHEMBL19559778 | 0.83 | PPARG (0.38) | PPARGMCL1FFAR1ADRB2ADRB3 | |
| SCHEMBL19559682 | 0.82 | PPARG (0.35) | PPARGMCL1FFAR1ADRB2ADRB3 | |
| SCHEMBL14213708 | 0.82 | PPARG (0.41) | PPARGFFAR1ADRB2ADRB3ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513070-B1 | PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES | CIRIUS THERAPEUTICS INC (US) | 2017-11-08 | — | — | EP | disclosed |