Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 14/20 | 0.52 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15550558 | 0.84 | PDE10A (0.50) | PDE10AHTTHSD11B1 | |
| SCHEMBL15690117 | 0.74 | PDE10A (0.41) | PDE10AHTT | |
| SCHEMBL20088561 | 0.74 | PDE10A (0.38) | PDE10ACRHR1HTTCDK4CCND1 | |
| SCHEMBL12245890 | 0.71 | PDE10A (0.38) | PDE10ACRHR1CDK4CCND1HAVCR2 | |
| SCHEMBL462808 | 0.71 | PDE10A (0.38) | PDE10ACRHR1CDK4CCND1HAVCR2 | |
| SCHEMBL15538187 | 0.70 | PDE10A (1.00) | PDE10A | |
| SCHEMBL24393151 | 0.68 | HTT (0.38) | PDE10ACRHR1HTTCDK4CCND1 | |
| SCHEMBL10285829 | 0.67 | HAVCR2 (0.60) | HAVCR2 | |
| SCHEMBL462807 | 0.67 | HAVCR2 (0.60) | HAVCR2 | |
| SCHEMBL462817 | 0.67 | PDE10A (0.38) | PDE10ACRHR1HTTHAVCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855455-B1 | TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-11-08 | — | — | EP | disclosed |