Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 6/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19563614 | 0.79 | SCN8A (0.40) | SCN8ASCN10A | |
| SCHEMBL20638673 | 0.78 | MRGPRX4 (0.46) | SCN8ASCN10A | |
| SCHEMBL4439280 | 0.77 | SLC6A4 (0.53) | SCN8ASCN10ASLC6A4PIK3CDPIK3CA | |
| SCHEMBL20431878 | 0.75 | SCN10A (0.47) | SCN8ASCN10ASLC6A4 | |
| SCHEMBL26615701 | 0.73 | EPAS1 (0.43) | SCN8ASCN10ASLC6A4AR | |
| SCHEMBL26615856 | 0.73 | SCN8A (0.40) | SCN8ASCN10ASLC6A4 | |
| SCHEMBL19563657 | 0.73 | SCN10A (0.48) | SCN8ASCN10A | |
| SCHEMBL4440723 | 0.73 | MEN1 (0.48) | SLC6A4ARPIK3CDPIK3CAPIK3CB | |
| SCHEMBL19563717 | 0.72 | AR (0.47) | SLC6A4AR | |
| SCHEMBL4446770 | 0.72 | EPAS1 (0.49) | SCN8ASCN10ASLC6A4ARPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022175-B1 | SULFONAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-11-08 | — | — | EP | disclosed |