Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 2/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 6/20 | 0.46 |
| ▸ | JAK1 | P23458 | 6/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19567519 | 0.85 | CARM1 (0.50) | CARM1PRMT6JAK2JAK1KDM1A | |
| SCHEMBL19567412 | 0.85 | CARM1 (0.50) | CARM1PRMT6JAK2JAK1KDM1A | |
| SCHEMBL23514508 | 0.85 | CARM1 (0.50) | CARM1PRMT6JAK2JAK1KDM1A | |
| SCHEMBL19567376 | 0.83 | CARM1 (0.48) | CARM1PRMT6JAK2JAK1KDM1A | |
| SCHEMBL19567521 | 0.82 | CARM1 (0.47) | CARM1PRMT6JAK2JAK1KDM1A | |
| SCHEMBL2732150 | 0.78 | CARM1 (0.63) | CARM1PRMT6KDM1AMAOAMAOB | |
| SCHEMBL24093079 | 0.77 | CARM1 (0.51) | CARM1PRMT6JAK2JAK1KDM1A | |
| SCHEMBL19567373 | 0.77 | CARM1 (0.51) | CARM1PRMT6JAK2JAK1KDM1A | |
| SCHEMBL19567514 | 0.77 | CARM1 (0.51) | CARM1PRMT6JAK2JAK1KDM1A | |
| Hydrochloric Acid SCHEMBL4879048 | 0.77 | CARM1 (0.62) | CARM1PRMT6KDM1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452464-B1 | PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF | HOFFMANN LA ROCHE (CH) | 2021-12-15 | — | — | EP | disclosed |
| WO-2017191098-A1 | PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-11-09 | — | — | WO | disclosed |