Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.67 |
| ▸ | EZH1 | Q92800 | 3/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | EED | O75530 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.64 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.64 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.64 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.64 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23030040 | 0.87 | EZH2 (0.72) | EZH2EZH1NR1I2EEDABCB11 | |
| SCHEMBL21041275 | 0.86 | EZH2 (0.76) | EZH2EZH1NR1I2EEDABCB11 | |
| SCHEMBL19570209 | 0.85 | EZH2 (0.54) | EZH2 | |
| SCHEMBL16545673 | 0.84 | EZH2 (0.69) | EZH2EZH1NR1I2EEDABCB11 | |
| SCHEMBL18400601 | 0.84 | EZH2 (0.80) | EZH2EZH1NR1I2EEDABCB11 | |
| SCHEMBL23462987 | 0.83 | EZH2 (0.83) | EZH2EZH1NR1I2EEDABCB11 | |
| SCHEMBL13276603 | 0.82 | EZH2 (0.78) | EZH2EZH1NR1I2EEDABCB11 | |
| SCHEMBL19391684 | 0.82 | EZH2 (0.83) | EZH2EZH1NR1I2EEDABCB11 | |
| SCHEMBL30077555 | 0.81 | EZH2 (0.72) | EZH2EZH1NR1I2EEDABCB11 | |
| SCHEMBL19391706 | 0.81 | EZH2 (0.67) | EZH2EZH1NR1I2EEDABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017192290-A1 | METHODS OF TREATING CANCERS OVEREXPRESSING CARM1 WITH EZH2 INHIBITORS AND PLATINUM-BASED ANTINEOPLASTIC DRUGS | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2017-11-09 | — | — | WO | disclosed |