SCHEMBL1957532

CN1CCC(Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CC(C)(C)CC5)CC4)cc3Oc3cccc(Cl)c3)cc2[N+](=O)[O-])C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	BCL2	P10415	19/20	1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1959730	1.00	BCL2 (1.00)	BCL2
SCHEMBL2533508	1.00	BCL2 (1.00)	BCL2
SCHEMBL1957185	0.97	BCL2 (1.00)	BCL2
SCHEMBL1957890	0.94	BCL2 (1.00)	BCL2
SCHEMBL1956022	0.94	BCL2 (1.00)	BCL2
SCHEMBL1957781	0.94	BCL2 (1.00)	BCL2
SCHEMBL1959257	0.94	BCL2 (1.00)	BCL2
SCHEMBL1958507	0.93	BCL2 (1.00)	BCL2
SCHEMBL1956834	0.93	BCL2 (1.00)	BCL2
SCHEMBL1956212	0.93	BCL2 (1.00)	BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2507211-A1	APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES	Abbott Laboratories (US)	2012-10-10	—	—	EP	claimed
WO-2011068560-A1	APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES	ABBOTT LABORATORIES (US)	2011-06-09	—	—	WO	claimed
EP-2507211-A1	APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES	Abbott Laboratories (US)	2012-10-10	—	—	EP	disclosed
WO-2011068560-A1	APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES	ABBOTT LABORATORIES (US)	2011-06-09	—	—	WO	disclosed