Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 3/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.43 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | NPY4R | P50391 | 6/20 | 0.38 |
| ▸ | NPY1R | P25929 | 4/20 | 0.38 |
| ▸ | NPY2R | P49146 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.37 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | RRM1 | P23921 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29714926 | 0.84 | FOLH1 (0.47) | ANPEPRNPEPDNPEPSLC7A5NPY4R | |
| SCHEMBL27903157 | 0.84 | FOLH1 (0.47) | ANPEPRNPEPDNPEPSLC7A5NPY4R | |
| SCHEMBL1711582 | 0.84 | FOLH1 (0.47) | ANPEPRNPEPDNPEPSLC7A5NPY4R | |
| SCHEMBL19576167 | 0.84 | NPY4R (0.44) | ANPEPRNPEPDNPEPNPY4RNPY1R | |
| SCHEMBL20997125 | 0.82 | NPY4R (0.41) | ANPEPRNPEPDNPEPNPY4RNPY1R | |
| SCHEMBL29714936 | 0.81 | FOLH1 (0.47) | NPY4RNPY1RNPY2RNPY5RKISS1R | |
| SCHEMBL29714940 | 0.80 | FOLH1 (0.43) | SLC7A5NPY4RNPY1RNPY2RNPY5R | |
| SCHEMBL29423522 | 0.78 | NPY4R (0.47) | NPY4RNPY1RNPY2RNPY5R | |
| SCHEMBL20997332 | 0.78 | NPY4R (0.39) | ANPEPRNPEPDNPEPNPY4RNPY1R | |
| SCHEMBL29887149 | 0.78 | BACE1 (0.43) | NPY4RNPY1RNPY2RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017191579-A1 | AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE | NOVARTIS AG (CH) | 2017-11-09 | — | — | WO | disclosed |