Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45535 | 0.93 | SLC34A2 (0.64) | SLC34A2RAF1BRAFKDM4EROCK2 | |
| SCHEMBL5999719 | 0.93 | SLC34A2 (0.65) | SLC34A2RAF1BRAFKDM4EROCK2 | |
| SCHEMBL46478 | 0.92 | SLC34A2 (0.50) | SLC34A2RAF1BRAFNAMPTKDM4E | |
| SCHEMBL39856 | 0.91 | SLC34A2 (0.54) | SLC34A2RAF1BRAFKDM4EMAPT | |
| SCHEMBL19580034 | 0.91 | SLC34A2 (0.59) | SLC34A2RAF1BRAFROCK2ROCK1 | |
| SCHEMBL6000093 | 0.91 | SLC34A2 (0.54) | SLC34A2RAF1BRAFKDM4ENPSR1 | |
| SCHEMBL19579976 | 0.90 | SLC34A2 (0.63) | SLC34A2RAF1BRAFKDM4EROCK2 | |
| SCHEMBL46763 | 0.89 | SLC34A2 (0.55) | SLC34A2RAF1BRAFKDM4ENPSR1 | |
| SCHEMBL46430 | 0.89 | SLC34A2 (0.47) | SLC34A2RAF1BRAFKDM4ENPSR1 | |
| SCHEMBL6002055 | 0.89 | SLC34A2 (0.51) | SLC34A2RAF1BRAFKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2017-11-15 | — | — | EP | claimed |