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SCHEMBL1958014

SCHEMBL1958014

CC(C)(C)C[C@@H]1N[C@@H](C(=O)Nc2ccc(C(N)=O)cc2)[C@H](c2cc(F)cc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ MDM2 Q00987 20/20 0.75
▸ TP53 P04637 9/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL222351 1.00 MDM2 (0.75) MDM2TP53
SCHEMBL222479 1.00 MDM2 (0.75) MDM2TP53
SCHEMBL12574482 0.94 MDM2 (0.73) MDM2TP53
SCHEMBL16788121 0.92 MDM2 (0.70) MDM2TP53
SCHEMBL220607 0.90 MDM2 (0.78) MDM2TP53
SCHEMBL1955501 0.90 MDM2 (0.78) MDM2TP53
SCHEMBL222177 0.90 MDM2 (0.78) MDM2TP53
SCHEMBL221003 0.90 MDM2 (0.77) MDM2TP53
SCHEMBL1958331 0.90 MDM2 (0.77) MDM2TP53
SCHEMBL220951 0.89 MDM2 (0.76) MDM2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011067185-A1 SPIROINDOLINONE PYRROLIDINES F. HOFFMANN-LA ROCHE AG (CH) 2011-06-09 — — WO disclosed