Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.53 |
| ▸ | HSF1 | Q00613 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19580763 | 0.82 | KDM4C (0.50) | KDM4CCYP1A2MAPTALDH1A1MEN1 | |
| SCHEMBL19580359 | 0.77 | KDM4C (0.51) | KDM4CHSF1MEN1KMT2A | |
| SCHEMBL17686461 | 0.77 | KDM4C (0.62) | KDM4CALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL19580369 | 0.72 | KDM4C (0.49) | KDM4CCYP1A2MAPTALDH1A1MEN1 | |
| SCHEMBL14738128 | 0.72 | KDM4C (0.43) | KDM4CCYP1A2CYP3A4MAPTCYP2C9 | |
| SCHEMBL21204939 | 0.71 | KDM4C (0.72) | KDM4CALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL17610172 | 0.70 | KDM4C (1.00) | KDM4C | |
| SCHEMBL17610212 | 0.68 | KDM4C (0.81) | KDM4CKMT2A | |
| SCHEMBL19580720 | 0.67 | KDM4C (0.48) | KDM4CCYP1A2ALDH1A1MEN1KMT2A | |
| SCHEMBL5076731 | 0.63 | KDM4E (0.49) | L3MBTL1MEN1KMT2AKDM4EMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10231957-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2019-03-19 | — | — | US | disclosed |
| US-20180271843-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-09-27 | — | — | US | disclosed |
| US-10016401-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170326116-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10016401-B2 | Histone demethylase inhibitors | KDM1B, KDM1A, KDM5A | KDM4C 12/4885HSF1 2685/4885CYP1A2 1918/4885 |
| US-20180271843-A1 | HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM1A, KDM5A | KDM4C 12/4885HSF1 2685/4885CYP1A2 1918/4885 |
| US-10231957-B2 | Histone demethylase inhibitors | KDM1B, KDM1A, KDM5A | KDM4C 12/4885HSF1 2685/4885CYP1A2 1918/4885 |
| US-20170326116-A1 | HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM1A, KDM5A | KDM4C 12/4885HSF1 2685/4885CYP1A2 1918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.