Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | PKM | P14618 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.49 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1958775 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTPKMPOLBKMT2A | |
| SCHEMBL2481745 | 0.78 | BCL2L1 (0.58) | SMN1; SMN2MAPTPKMPOLBKMT2A | |
| SCHEMBL2481747 | 0.78 | BCL2L1 (0.58) | SMN1; SMN2MAPTPKMPOLBKMT2A | |
| SCHEMBL1960341 | 0.75 | SMN1; SMN2 (0.86) | SMN1; SMN2MAPTPKMPOLBKMT2A | |
| SCHEMBL21542217 | 0.74 | MAPT (0.73) | SMN1; SMN2MAPTPKMPOLBKMT2A | |
| SCHEMBL30349527 | 0.74 | MAPT (0.73) | SMN1; SMN2MAPTPKMPOLBKMT2A | |
| SCHEMBL1958230 | 0.74 | MAPT (0.56) | SMN1; SMN2MAPTPKMPOLBKMT2A | |
| SCHEMBL17555037 | 0.74 | BCL2L1 (0.65) | SMN1; SMN2MAPTPKMPOLBKMT2A | |
| SCHEMBL1957469 | 0.73 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTPKMPOLBKMT2A | |
| SCHEMBL2481610 | 0.72 | SMN1; SMN2 (0.93) | SMN1; SMN2MAPTPKMPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507229-A1 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068561-A1 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |