Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 13/20 | 0.77 |
| ▸ | FGFR4 | P22455 | 10/20 | 0.77 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.77 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.77 |
| ▸ | LCK | P06239 | 3/20 | 0.77 |
| ▸ | JAK2 | O60674 | 2/20 | 0.77 |
| ▸ | ABL1 | P00519 | 2/20 | 0.77 |
| ▸ | INSR | P06213 | 2/20 | 0.77 |
| ▸ | FYN | P06241 | 2/20 | 0.77 |
| ▸ | YES1 | P07947 | 2/20 | 0.77 |
| ▸ | LYN | P07948 | 2/20 | 0.77 |
| ▸ | RET | P07949 | 2/20 | 0.77 |
| ▸ | MET | P08581 | 2/20 | 0.77 |
| ▸ | ROS1 | P08922 | 2/20 | 0.77 |
| ▸ | KIT | P10721 | 2/20 | 0.77 |
| ▸ | SRC | P12931 | 2/20 | 0.77 |
| ▸ | BRAF | P15056 | 2/20 | 0.77 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.77 |
| ▸ | FLT1 | P17948 | 2/20 | 0.77 |
| ▸ | TYK2 | P29597 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Infigratinib SCHEMBL374435 | 0.87 | FGFR3 (1.00) | FGFR3FGFR4FGFR1FGFR2LCK | |
| SCHEMBL2013451 | 0.84 | FGFR3 (0.91) | FGFR3FGFR4FGFR1FGFR2LCK | |
| Infigratinib SCHEMBL14893408 | 0.84 | FGFR3 (1.00) | FGFR3FGFR4FGFR1FGFR2LCK | |
| SCHEMBL2011033 | 0.84 | FGFR3 (0.91) | FGFR3FGFR4FGFR1FGFR2LCK | |
| SCHEMBL19338005 | 0.84 | FGFR3 (0.91) | FGFR3FGFR4FGFR1FGFR2LCK | |
| SCHEMBL16383021 | 0.83 | FGFR3 (0.92) | FGFR3FGFR4FGFR1FGFR2LCK | |
| SCHEMBL19952869 | 0.83 | FGFR3 (0.73) | FGFR3FGFR4FGFR1FGFR2LCK | |
| SCHEMBL23281490 | 0.83 | FGFR3 (0.91) | FGFR3FGFR4FGFR1FGFR2LCK | |
| SCHEMBL19848824 | 0.83 | FGFR3 (0.84) | FGFR3FGFR4FGFR1FGFR2LCK | |
| SCHEMBL12596389 | 0.83 | FGFR3 (0.91) | FGFR3FGFR4FGFR1FGFR2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9815898-B2 | Antibody molecules to PD-1 and uses thereof | NOVARTIS AG (CH) | 2017-11-14 | — | — | US | disclosed |
| US-9815898-B2 | Antibody molecules to PD-1 and uses thereof | NOVARTIS AG (CH) | 2017-11-14 | — | — | US | disclosed |