Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A3 | P48764 | 9/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13286042 | 0.90 | MEN1 (0.47) | SLC9A3MEN1KMT2ALMNAMAPT | |
| SCHEMBL20404536 | 0.88 | SLC9A3 (0.39) | SLC9A3MEN1KMT2ALMNAMAPT | |
| SCHEMBL19593826 | 0.87 | SLC9A3 (0.39) | SLC9A3MEN1KMT2ALMNAMAPT | |
| SCHEMBL13286043 | 0.86 | SLC9A3 (0.46) | SLC9A3 | |
| SCHEMBL7023341 | 0.86 | SLC9A3 (0.48) | SLC9A3 | |
| SCHEMBL7651694 | 0.86 | SLC9A3 (0.48) | SLC9A3 | |
| SCHEMBL22371397 | 0.85 | SLC9A3 (0.40) | SLC9A3MEN1KMT2ALMNAMAPT | |
| SCHEMBL16638603 | 0.84 | SLC9A3 (0.51) | SLC9A3 | |
| SCHEMBL19594048 | 0.84 | ESR1 (0.43) | SLC9A3TUBB1 | |
| SCHEMBL24380143 | 0.84 | SLC9A3 (0.54) | SLC9A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2384318-B1 | COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS | ARDELYX INC (US) | 2017-11-15 | — | — | EP | disclosed |