Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A3 | P48764 | 10/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19593632 | 0.88 | SLC9A3 (0.42) | SLC9A3TUBB1 | |
| SCHEMBL19593883 | 0.88 | ESR1 (0.40) | SLC9A3ESR1TUBB1AKR1C3 | |
| SCHEMBL19594048 | 0.84 | ESR1 (0.43) | SLC9A3ESR1TUBB1AKR1C3 | |
| SCHEMBL2565950 | 0.84 | AKR1C3 (0.53) | SLC9A3ESR1TUBB1AKR1C3 | |
| SCHEMBL2565952 | 0.84 | AKR1C3 (0.53) | SLC9A3ESR1TUBB1AKR1C3 | |
| SCHEMBL23469949 | 0.83 | ESR1 (0.42) | SLC9A3ESR1TUBB1AKR1C3 | |
| SCHEMBL2568719 | 0.81 | SLC9A3 (0.49) | SLC9A3 | |
| SCHEMBL2568722 | 0.81 | SLC9A3 (0.49) | SLC9A3 | |
| SCHEMBL19593608 | 0.81 | ESR1 (0.41) | SLC9A3ESR1TUBB1AKR1C3 | |
| SCHEMBL2571778 | 0.79 | SLC9A3 (0.47) | SLC9A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939964-A1 | COMBINATIONS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS | Ardelyx, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |
| EP-3351248-B1 | COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS | ARDELYX INC (US) | 2021-06-09 | — | — | EP | disclosed |
| EP-2384318-B1 | COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS | ARDELYX INC (US) | 2017-11-15 | — | — | EP | disclosed |