Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.42 |
| ▸ | SLC9A3 | P48764 | 11/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23469949 | 0.87 | ESR1 (0.42) | TUBB1SLC9A3 | |
| SCHEMBL19593632 | 0.84 | SLC9A3 (0.42) | TUBB1SLC9A3 | |
| SCHEMBL20404624 | 0.83 | SLC9A3 (0.36) | TUBB1SLC9A3 | |
| SCHEMBL2572999 | 0.83 | SLC9A3 (0.50) | SLC9A3 | |
| SCHEMBL2572996 | 0.83 | SLC9A3 (0.50) | SLC9A3 | |
| SCHEMBL19661929 | 0.83 | SLC9A3 (0.48) | SLC9A3 | |
| SCHEMBL2577308 | 0.79 | SLC9A3 (0.60) | SLC9A3 | |
| SCHEMBL2577309 | 0.79 | SLC9A3 (0.60) | SLC9A3 | |
| SCHEMBL19593832 | 0.77 | SLC9A3 (0.39) | TUBB1SLC9A3 | |
| SCHEMBL2575299 | 0.76 | SLC9A3 (0.49) | SLC9A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2384318-B1 | COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS | ARDELYX INC (US) | 2017-11-15 | — | — | EP | disclosed |