Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46674 | 0.93 | KDM5A (0.43) | RAF1BRAFDRD4MEN1KMT2A | |
| SCHEMBL46675 | 0.91 | DRD4 (0.43) | RAF1BRAFDRD4MEN1KMT2A | |
| SCHEMBL15432681 | 0.88 | SMN1; SMN2 (0.40) | RAF1BRAFDRD4LMNAMAPT | |
| SCHEMBL19595982 | 0.87 | RAF1 (0.44) | RAF1BRAFMEN1KMT2AALDH1A1 | |
| SCHEMBL18484260 | 0.87 | MAPK14 (0.41) | RAF1BRAFDRD4MEN1KMT2A | |
| SCHEMBL15444422 | 0.86 | BRAF (0.38) | RAF1BRAFDRD4MAPTHTT | |
| SCHEMBL46783 | 0.86 | KDM1A (0.47) | RAF1BRAFLMNAMAPT | |
| SCHEMBL46836 | 0.85 | CNR2 (0.42) | DRD4MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6001362 | 0.85 | SLC34A2 (0.48) | RAF1BRAFMAPK14WDR5 | |
| SCHEMBL15432700 | 0.85 | RAF1 (0.48) | RAF1BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2017-11-15 | — | — | EP | disclosed |