Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | PKM | P14618 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30074947 | 1.00 | KMT2A (0.47) | KMT2AMEN1MAPTPKMMAPK1 | |
| SCHEMBL1957524 | 0.90 | MAPT (0.47) | KMT2AMEN1MAPTPKMMAPK1 | |
| SCHEMBL2408475 | 0.89 | MAPT (0.52) | KMT2AMEN1MAPTPKMMAPK1 | |
| SCHEMBL29750920 | 0.82 | MAPT (0.45) | KMT2AMEN1MAPTPKMMAPK1 | |
| SCHEMBL1699969 | 0.81 | MAPT (0.57) | KMT2AMEN1MAPTPKMMAPK1 | |
| SCHEMBL1700196 | 0.81 | MAPT (0.57) | KMT2AMEN1MAPTPKMMAPK1 | |
| SCHEMBL1699967 | 0.81 | MAPT (0.57) | KMT2AMEN1MAPTPKMMAPK1 | |
| SCHEMBL30075042 | 0.81 | MAPT (0.57) | KMT2AMEN1MAPTPKMMAPK1 | |
| SCHEMBL1957964 | 0.79 | BCL2 (0.43) | MAPTMAPK1 | |
| SCHEMBL30622006 | 0.79 | BCL2L1 (0.54) | KMT2AMEN1MAPTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507211-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | claimed |
| WO-2011068560-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | claimed |