Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | FABP7 | O15540 | 1/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19607654 | 1.00 | TSHR (0.44) | TSHRFABP7FABP5ALDH1A1NPSR1 | |
| Trifluoroacetic Acid SCHEMBL28841794 | 0.92 | KDM1A (0.41) | TSHRFABP7FABP5ALDH1A1NPSR1 | |
| SCHEMBL29282055 | 0.82 | SLC18A2 (0.43) | TSHRNPSR1MAPK1SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL11628428 | 0.81 | KDM4E (0.44) | TSHRALDH1A1NPSR1MAPK1SLC6A2 | |
| SCHEMBL9222839 | 0.79 | TSHR (0.46) | TSHRFABP7FABP5ALDH1A1NPSR1 | |
| SCHEMBL29171401 | 0.78 | GLA (0.45) | TSHRFABP7FABP5ALDH1A1L3MBTL1 | |
| SCHEMBL29171400 | 0.78 | GLA (0.45) | TSHRFABP7FABP5ALDH1A1L3MBTL1 | |
| SCHEMBL27534958 | 0.78 | HTR2C (0.45) | TSHRFABP7FABP5ALDH1A1L3MBTL1 | |
| SCHEMBL4143242 | 0.77 | TSHR (0.44) | TSHRALDH1A1NPSR1SLC6A2SLC6A3 | |
| SCHEMBL26998916 | 0.77 | TSHR (0.44) | TSHRALDH1A1NPSR1SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10398702-B2 | Dimeric compounds | HOFFMANN-LA ROCHE INC. (US) | 2019-09-03 | — | — | US | disclosed |
| US-20190134050-A1 | DIMERIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2019-05-09 | — | — | US | disclosed |
| WO-2017194390-A1 | DIMERIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190134050-A1 | DIMERIC COMPOUNDS | BIRC5, BID, BIRC2 | TSHR 3115/4885FABP7 584/4885FABP5 139/4885 |
| US-10398702-B2 | Dimeric compounds | BIRC5, BID, BIRC2 | TSHR 3115/4885FABP7 584/4885FABP5 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.