Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.59 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19611147 | 0.93 | PIK3CA (0.61) | PIK3CAPIK3R1 | |
| SCHEMBL19611153 | 0.92 | PIK3CA (0.61) | PIK3CAPIK3R1 | |
| SCHEMBL2378463 | 0.80 | PIK3CA (0.67) | PIK3CAPIK3R1 | |
| SCHEMBL19623407 | 0.80 | PIK3CA (0.69) | PIK3CAPIK3R1 | |
| SCHEMBL12247569 | 0.76 | PIK3CA (0.80) | PIK3CAPIK3R1 | |
| SCHEMBL2378217 | 0.75 | PIK3CA (1.00) | PIK3CAPIK3R1 | |
| SCHEMBL19611155 | 0.74 | PIK3CA (0.62) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL12247571 | 0.74 | PIK3CA (0.70) | PIK3CAPIK3R1 | |
| SCHEMBL12246546 | 0.73 | PIK3CA (0.67) | PIK3CAPIK3R1 | |
| SCHEMBL2377820 | 0.73 | PIK3CA (0.81) | PIK3CAPIK3R1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | claimed |